Sat Sep 19, 2020 12:39
Point-of-Care Prototype Blood Test Reveals Brain Injuries in Minutes
TEHRAN (FNA)- Generally, the way doctors detect traumatic brain injuries is through a CT scan, but recently we've seen how a protein called GFAP could play an important role in more prompt diagnoses. A blood test that uses this biomarker to reveal the severity of brain tissue damage in a matter of hours was recently approved for clinical use, but the authors of a new study are now setting their sights on a point-of-care solution that can deliver results within 15 minutes.

The US Food and Drug Administration approved the first blood test for concussion in 2018, ticking off on a diagnostic tool that could reveal intracranial lesions through elevated levels of GFAP in the blood. With the ability to return results in three or four hours, this marked a significant breakthrough when it comes to treating brain injuries, as it makes it easier to determine which patients require expensive CT scans and which ones don’t.

What could prove even more useful, however, is an on-the-spot testing device that can make these kinds of assessments in minutes rather than hours. Working towards this goal, scientists at the University of Pittsburgh conducted a study involving almost 1,500 traumatic brain injury patients and their blood, to investigate whether the warning signs can be picked up earlier in the piece.

The subjects’ plasma was collected and analyzed using a prototype point-of-care device, with the scientists looking to GFAP levels to predict intracranial brain abnormalities on the CT scans taken thereafter. These results were compared to another biomarker released into the blood in response to traumatic brain injuries called S100B.

While levels of both proteins were heightened in the point-of-care analysis, GFAP substantially outperformed S100B as a diagnostic marker for traumatic brain injury. In fact, the device performed so well at using GFAP levels to predict the need for CT scans, the team says it can now provide a springboard for real-world solutions that offer results far more quickly.

“Our results validate a POC platform prototype GFAP assay that delivers results in minutes (< 15 min) versus hours for the current FDA-cleared assay,” the scientists write in their paper.

One of the ways the team sees this technology being used is through a handheld device called an i-STAT, which is already in use by health care providers as a way of carrying out certain blood tests in minutes. The scientists estimate that used in this way, the approach could slash the number of unnecessary CT scans by as much as 20 percent.

“Knowing this protein can show the severity of a TBI through a simple blood test is promising when considering we can use a device that already is in widespread use in hospitals, doctors’ offices and urgent care facilities,” says lead author David Okonkwo. “All we would need to do is add an extra cartridge to the device to analyze blood for the GFAP protein.”




Bottom top
English Channel: Two Children Among Four Migrants Killed After Boat Sinks Trying to Reach UK

TEHRAN (FNA)- Two children are among four migrants who died after a boat sank as they tried to reach the UK.
Health Minister: Iran-Made Rapid Coronavirus Tests Ready for Market Supply

TEHRAN (FNA)- Iranian Health Minister Saeed Namaki announced on Wednesday that the country’s scientists have succeeded in production of rapid coronavirus-diagnosis tests which will enter the market soon.
Protesters Gather Outside DC Police Station over Deadly Moped Crash, Police Unleash Tear Gas, Stun Grenades

TEHRAN (FNA)- Protesters gathered outside of a Washington, D.C., police station Tuesday to request more information about a Friday moped crash that left a man dead after police tried to pull him over for not wearing a helmet.
Iran Records 6,824 New Coronavirus Cases

TEHRAN (FNA)- The Iranian health ministry announced on Wednesday that 6,824 new cases of coronavirus infection have been identified across the country during the past 24 hours, adding that 415 patients have passed away during the same period.
Iran: 6-Month Exports of Semnan Province Top $120mln

TEHRAN (FNA)- Semnan province in Northern Iran has exported 116,000 tons of products worth $120.4 million during the first six months of the current Iranian year (March 20-Sept. 21), local Director General of the Customs Administration Ali Sa’doddin said.
Russia Documents Record-High 346 Deaths from COVID-19 in Past 24 Hours

TEHRAN (FNA)- Russia has documented 346 deaths from coronavirus in the past 24 hours, which is a record daily high since the start of the pandemic, the anti-coronavirus crisis center informed on Wednesday.
Dow Futures Sink 500 Points as Wall Street Grapples with Rising COVID Cases

TEHRAN (FNA)- US stock futures fell sharply early Wednesday as investors feared an increase in coronavirus infections could halt the recovering economy.
Survey: No European Countries Would Reelect Trump Except Poland

TEHRAN (FNA)- If US President Donald Trump was facing an election in Europe he would have almost no chance at winning and would only get about 17% of the vote, according to a survey published on Wednesday by German researchers.
Pelosi Says No COVID-19 Relief Before Election Day, Blames White House for Failing 'Miserably'

TEHRAN (FNA)- House Speaker Nancy Pelosi ended any hopes of a COVID-19 relief bill before the Election Day, blaming the White House for failing "miserably" in a letter to House Democrats on Tuesday.
Report: Patients Discharged from UK Hospitals without COVID Test Results

TEHRAN (FNA)- Almost half of hospital patients have been discharged without receiving the results of their coronavirus test – including some patients who were sent to care homes, new research revealed.
Report: White Supremacist Group Training for Violence in Case Trump Loses Election

TEHRAN (FNA)- A white supremacist group is training for violence in case President Donald Trump loses the election, according to a report.
Iran’s Judiciary Chief: Normalization Deals No Guarantee for Israel’s Survival

TEHRAN (FNA)- Iran’s Judiciary Chief Seyed Ebrahim Rayeesi underlined on Tuesday that normalization deals by some Arab states may not protect Israel from annihilation.
Over 0.7mln Tons of Goods Exported via Iran's Southeastern Borders in 7 Months

TEHRAN (FNA)- 705,483 tons of various products were exported from Sistan and Balouchestan province’s terminals and border markets during the first 7 months of the current Iranian year (March 20-October 21), Head of the provincial transportation department Ayoub Kord said.
Deputy FM: Those Involved in Ukrainian Plane Crash to Face Punishment

TEHRAN (FNA)- Iranian Deputy Foreign Minister for International and Legal Affairs Mohsen Baharvand said that Tehran is ready for further talks with Kiev on the crashed plane, assuring the punishment of all those guilty in the incident.
Grand Juror: Officers' Actions Night Breonna Taylor Was Killed Were 'Criminal'

TEHRAN (FNA)- Two grand jurors who presided over the case of Breonna Taylor’s death spoke out in a new interview with CBS News, saying they found fault with actions of the Louisville, Ky., police officers involved.