Medicine
Wed Aug 05, 2020 12:44
Regeneron's COVID-19 Antibody-Drug Cocktail Treats SARS-CoV-2 Virus in Animals
TEHRAN (FNA)- Now, Regeneron Pharmaceuticals says its COVID-19 antibody-drug cocktail under development prevented and treated the disease in monkeys and hamsters, showing promise that it may work in humans.

The company's cocktail of two monoclonal antibodies, called the REGN-COV-2, was able to prevent and treat the disease in rhesus macaques and hamsters.

Further, the scientists behind the project said the animals did not show any signs of increased viral load or worsening conditions after treatment.

The US biotech company said that the animal study, which has not yet been peer-reviewed, showed that the two monoclonal antibodies were able to almost completely block the establishment of virus infection. The researchers also said the drugs were able to reduce infection in a second study in which the animals were infected with a higher level of the virus.

The company said that the infected animals treated with REGN-COV2 cleared the virus faster than those who were given a placebo. The data suggests that the therapy may offer clinical benefit in both the prevention and treatment of COVID-19.

Promising results

Regeneron Pharmaceuticals announced earlier in July that it has been awarded a $450 million contract with the U.S. government, as part of its Operation Warp Speed program, to manufacture and supply REGN-COV2, the company's investigational double-antibody cocktail that is being trialed as a treatment for COVID-19.

What is REGN-COV2?

Scientists at Regeneron studied thousands of fully-human antibodies produced by laboratory mice, called the VelovImmune. These mice were genetically engineered to have a human immune system with antibodies identified from humans who have recovered from the novel coronavirus infection.

The team chose two of the most potent, robust, and virus-neutralizing antibodies to produce REGN-COV2. To work, the drug bind to the receptor-binding domain (RBD) of the virus's spike protein, reducing the ability of the virus to evade treatment and protects against spike variants that have emerged in the human population.

The company used the same technique and cocktail approach to develop REGN-EB3, a novel antibody treatment for Ebola, which is now being reviewed by the Food and Drug Administration (FDA).

COVID-19 global toll

The coronavirus pandemic has so far killed more than 700,000 worldwide. The United States and Brazil remain as the countries with the highest number of cases, at more than 4.77 million and 2.8 million, respectively.

The death toll in the US has topped 156,000, while Brazil trails behind, with at least 95,000 deaths. India, Russia, South Africa, and Mexico report an increasing number of cases, with more than 1.9 million, 859,000, 521,000, and 449,000 confirmed cases, respectively.

The epicenter of the pandemic has moved from Europe to the United States and South America. Brazil, Peru, Chile, and Colombia have skyrocketing cases.

 

 

 

 

Bottom top
Action Against Israeli Arms

TEHRAN (FNA)- Pro-Palestine activists continue to occupy the rooftop of arms component factory, UAV Engines who make drone parts for Israeli firm Elbit Systems. The protestors are calling for Elbit factories and their affiliates in the UK to be closed immediately. Elbit Systems is the chief supplier of drones to the Israeli Occupation Army with devastating consequences for Palestinian lives, as Amina Taylor explains. [VIDEO]
US: Oregon Wildfires Leave Trail of Devastation in Town of Gates

TEHRAN (FNA)- The wildfires in Oregon left a trail of devastation in their wake in the small town of Gates, as seen. The local primary school can be seen gutted by fire, while burnt out lorries and other fire damaged buildings can also be seen in the area. [VIDEO]
US: Anti Trump, BLM Protesters Demonstrate in Philadelphia

TEHRAN (FNA)- Everywhere US President Trump goes on the campaign trail he seems to bring BLM protest. In Philadelphia, the Trump supporters and his haters and BLM are facing off. “Go home racists” chants the Black Lives Matter/anti-fascist crowd to the Trump supporters outside the President’s town hall in Philadelphia. [PHOTOS]
Hurricane Sally: Deadly Storm Leaves 550,000 without Power in US

TEHRAN (FNA)- Tropical Storm Sally has left more than half a million Americans without power as its torrential rains and storm surges lashed the US Gulf coast. [PHOTOS]
Greece: Migrants Continue Lodging in Makeshift Tents in Moria as Authorities Struggle to Relocate them to New Camp

TEHRAN (FNA)- Asylum seekers from the devastated Moria refugee camp continued to lodge in makeshift tents next to a supermarket parking, as seen in drone footage from Wednesday, while the Greek authorities were reported saying they struggle to convince migrants to move into the new temporary camp. [VIDEO]
Ecuador: Police Disperse Anti-Austerity Protest with Water Cannons

TEHRAN (FNA)- Ecuadorian police used water cannons to disperse protesters who took to the streets of Quito to demonstrate against austerity measures taken by the government. [VIDEO]
Thousands of Migrants Search for Shelter after Fire Destroys Moria Camp

TEHRAN (FNA)- More than 12,000 people, mostly refugees from Afghanistan, Africa and Syria, are without shelter and are having to sleep out in the open without proper sanitation after the fire tore through the Moria migrant camp on the island of Lesbos, Greece. [PHOTOS]
COVID-19: Use Masks to Help Slow Spread

TEHRAN (FNA)- Director of the Centers for Disease Control and Prevention Robert Redfield has raised eyebrows after telling the Senate face masks are a “powerful public health tool” and may even be more effective against Covid-19 than vaccines. [PHOTOS]
Iran, Azerbaijan Vow to Expand Economic Cooperation

TEHRAN (FNA)- Iranian Ambassador to Baku Seyed Abbas Mousavi and Azeri Deputy Prime Minister Shahin Mustafayev in a meeting underlined the need to develop mutual cooperation, specially in economic fields.
VP: Iran-Russia Technological Cooperation on Right Track

TEHRAN (FNA)- Iran's Vice President for Science and Technology Sourena Sattari said on Thursday that grounds are ready for promoting scientific and technological cooperation, specially in area of advanced pharmaceutical technologies.
China Denies Connection with Company 'Monitoring' Indians, Including President, PM

TEHRAN (FNA)- The Chinese government claimed it has no connection with the Shenzhen-based company that has allegedly been monitoring thousands of Indians.
New Envoy Stresses Solidarity, Cooperation with Bosnia

TEHRAN (FNA)- Iranian new ambassador to Bosnia and Herzegovina Reza Qelichkhan and Director General of Protocols of Bosnian Ministry of Foreign Affairs Mirsad Bešić emphasized solidarity between Tehran and Sarajevo, and called for further expansion of ties between the two friendly nations.
Iranian, Pakistani Officials Discuss Bilateral Ties, Border Cooperation

TEHRAN (FNA)- Iranian Consul General in Quetta Hassan Darvishvand and Spokesman of the Government of Balochistan Province of Pakistan Liaquat Shahwani discussed development of bilateral relations, especially cooperation between the border provinces of the two countries in various fields, an arrived at an agreement.
Iran Nearing Full Production at Azar Oilfield

TEHRAN (FNA)- Azar oilfield is on the verge of attaining production capacity of 65,000 barrels of oil per day by using the ancillary facilities of the Central Processing Facility (CPF), an energy official announced.
Dissident: UAE Cracking Down Hard on Anti-Israel Sentiment with 10-Year Prison Sentences

TEHRAN (FNA)- A dissident Emirati activist said that the United Arab Emirates is cracking down hard on anti-Israel sentiment with 10-year prison sentences amid the Persian Gulf country’s push to establish formal relations with the Israeli regime.