Wed Aug 05, 2020 12:42
Large Clinical Trial Affirms Vitamin D Does Not Prevent Depression
TEHRAN (FNA)- The results of the largest clinical trial ever conducted into the relationship between vitamin D and depression suggest the vitamin does not improve mood or prevent depression. The trial did not investigate subjects with pre-existing vitamin D deficiencies.

Vitamin D has often been referred to as the “sunshine vitamin.” It is produced through exposing skin to sunlight. In darker winter months, people can often develop mild vitamin D deficiencies leading some researchers to hypothesize that it plays a significant role in seasonal affective disorder, a mild type of depression than only occurs in winter.

Low blood levels of vitamin D have frequently been observationally linked to higher rates of depression, but causality has never been effectively determined. A number of small randomized clinical trials have investigated whether vitamin D supplementation can prevent depression, or at least improve mood, in middle-aged or older subjects. Almost all of those trials found vitamin D supplementation does not prevent depression.

This new study investigating the relationship between vitamin D and depression was conducted as part of a larger clinical trial exploring preventative techniques for cardiovascular disease and cancer. The vitamin D arm of the trial involved 18,353 subjects with an average age of 67.

"One scientific issue is that you actually need a very large number of study participants to tell whether or not a treatment is helping to prevent development of depression," explains lead author on the new study, Olivia Okereke. "With nearly 20,000 people, our study was statistically powered to address this issue."

The cohort was randomly split between a placebo and active group, the active group taking 2,000 IU of cholecalciferol (vitamin D3) every day, with a follow-up of five years. By the end of the study the researchers suggest the results were clear. There was no statistically significant difference in incidences of depression between the vitamin D and placebo groups. Even more importantly, there wasn’t even a major difference in self-reported mood scores between the two groups across the long trial period.

The study did concentrate solely on subjects with healthy baseline vitamin D levels. Increases in those vitamin D levels were detected in the non-placebo cohort across the trial period, however, the researchers do note further study is needed to understand the potential effect of long-term, high-dose vitamin D supplementation on subjects with a clinical nutrient deficiency.

So, although the study can effectively suggest otherwise healthy older adults need not use vitamin D as a preventive measure against depression, it is still unclear whether serious deficiencies lead to mood imbalances or depression. Essentially, the study is another in a growing body of research finding vitamin supplements are fundamentally ineffective in people who are not nutritionally deficient.

Senior author on the paper, JoAnn Manson, does offer the pertinent reminder that this research does not mean people should immediately stop taking vitamin D, especially if they are following clinical advice. The essential vitamin may not prevent depression but it does a whole lot of important things, vital for general health.

"Vitamin D is known to be essential for bone and metabolic health, but randomized trials have cast doubt on many of the other presumed benefits,” says Manson.





Bottom top
Action Against Israeli Arms

TEHRAN (FNA)- Pro-Palestine activists continue to occupy the rooftop of arms component factory, UAV Engines who make drone parts for Israeli firm Elbit Systems. The protestors are calling for Elbit factories and their affiliates in the UK to be closed immediately. Elbit Systems is the chief supplier of drones to the Israeli Occupation Army with devastating consequences for Palestinian lives, as Amina Taylor explains. [VIDEO]
US: Oregon Wildfires Leave Trail of Devastation in Town of Gates

TEHRAN (FNA)- The wildfires in Oregon left a trail of devastation in their wake in the small town of Gates, as seen. The local primary school can be seen gutted by fire, while burnt out lorries and other fire damaged buildings can also be seen in the area. [VIDEO]
US: Anti Trump, BLM Protesters Demonstrate in Philadelphia

TEHRAN (FNA)- Everywhere US President Trump goes on the campaign trail he seems to bring BLM protest. In Philadelphia, the Trump supporters and his haters and BLM are facing off. “Go home racists” chants the Black Lives Matter/anti-fascist crowd to the Trump supporters outside the President’s town hall in Philadelphia. [PHOTOS]
Hurricane Sally: Deadly Storm Leaves 550,000 without Power in US

TEHRAN (FNA)- Tropical Storm Sally has left more than half a million Americans without power as its torrential rains and storm surges lashed the US Gulf coast. [PHOTOS]
Greece: Migrants Continue Lodging in Makeshift Tents in Moria as Authorities Struggle to Relocate them to New Camp

TEHRAN (FNA)- Asylum seekers from the devastated Moria refugee camp continued to lodge in makeshift tents next to a supermarket parking, as seen in drone footage from Wednesday, while the Greek authorities were reported saying they struggle to convince migrants to move into the new temporary camp. [VIDEO]
Ecuador: Police Disperse Anti-Austerity Protest with Water Cannons

TEHRAN (FNA)- Ecuadorian police used water cannons to disperse protesters who took to the streets of Quito to demonstrate against austerity measures taken by the government. [VIDEO]
Thousands of Migrants Search for Shelter after Fire Destroys Moria Camp

TEHRAN (FNA)- More than 12,000 people, mostly refugees from Afghanistan, Africa and Syria, are without shelter and are having to sleep out in the open without proper sanitation after the fire tore through the Moria migrant camp on the island of Lesbos, Greece. [PHOTOS]
COVID-19: Use Masks to Help Slow Spread

TEHRAN (FNA)- Director of the Centers for Disease Control and Prevention Robert Redfield has raised eyebrows after telling the Senate face masks are a “powerful public health tool” and may even be more effective against Covid-19 than vaccines. [PHOTOS]
Iran, Azerbaijan Vow to Expand Economic Cooperation

TEHRAN (FNA)- Iranian Ambassador to Baku Seyed Abbas Mousavi and Azeri Deputy Prime Minister Shahin Mustafayev in a meeting underlined the need to develop mutual cooperation, specially in economic fields.
VP: Iran-Russia Technological Cooperation on Right Track

TEHRAN (FNA)- Iran's Vice President for Science and Technology Sourena Sattari said on Thursday that grounds are ready for promoting scientific and technological cooperation, specially in area of advanced pharmaceutical technologies.
China Denies Connection with Company 'Monitoring' Indians, Including President, PM

TEHRAN (FNA)- The Chinese government claimed it has no connection with the Shenzhen-based company that has allegedly been monitoring thousands of Indians.
New Envoy Stresses Solidarity, Cooperation with Bosnia

TEHRAN (FNA)- Iranian new ambassador to Bosnia and Herzegovina Reza Qelichkhan and Director General of Protocols of Bosnian Ministry of Foreign Affairs Mirsad Bešić emphasized solidarity between Tehran and Sarajevo, and called for further expansion of ties between the two friendly nations.
Iranian, Pakistani Officials Discuss Bilateral Ties, Border Cooperation

TEHRAN (FNA)- Iranian Consul General in Quetta Hassan Darvishvand and Spokesman of the Government of Balochistan Province of Pakistan Liaquat Shahwani discussed development of bilateral relations, especially cooperation between the border provinces of the two countries in various fields, an arrived at an agreement.
Iran Nearing Full Production at Azar Oilfield

TEHRAN (FNA)- Azar oilfield is on the verge of attaining production capacity of 65,000 barrels of oil per day by using the ancillary facilities of the Central Processing Facility (CPF), an energy official announced.
Dissident: UAE Cracking Down Hard on Anti-Israel Sentiment with 10-Year Prison Sentences

TEHRAN (FNA)- A dissident Emirati activist said that the United Arab Emirates is cracking down hard on anti-Israel sentiment with 10-year prison sentences amid the Persian Gulf country’s push to establish formal relations with the Israeli regime.